DEXAMETHASONE DISODIUM PHOSPHATE

PRODUCT IDENTIFICATION
CAS NO. 50-02-2 (Base)
2392-39-4 (Sodium Phosphate)

DEXAMETHASONE DISODIUM PHOSPHATE
EINECS NO. 200-003-9, 219-243-0
FORMULA C22H30FO8P·2Na
MOL WT. 516.40

H.S. CODE

  

TOXICITY

 
SYNONYMS Dexamethasone Sodium Phosphate;
21-(Fosfato disódico) de dexametasona; 21-(Phosphate disodique) de dexamethasone; Disodium 9a-fluoro-16a-methylprednisolone-21-phosphate; Dexamethasone 21-phosphate disodium salt;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE White to off-white crystalline powder
MELTING POINT  
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 2 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION  & APPLICATIONS
Corticosteroid is a synthetic or naturally occurring 21-carbon steroid structure substances with four fused rings and vary functional branches attached to the ring system. Cholesterol and steroid hormones have this carbon skeleton. The term steroid refers to these three groups that contain a hydrogenated cyclopentano perhydro phenanthrene ring system. In restricted context for medical usage by non-endocrinologists, it refers to corticosteroids. Natural corticosteroids are elaborated by the adrenal cortex in response to physiological carbohydrate metabolism. According to their predominant biologic activity, they are divided into two major groups: glucocorticoid and mineralocorticoid. Glucocorticoid's chief function is to regulate carbohydrate, lipid, and protein metabolism and inhibit the release of ACTH (adrenocorticotropic hormone). Glucocorticoids also affect muscle tone and the microcirculation, participate in the maintenance of arterial blood pressure, increase gastric secretion, alter connective tissue response to injury, impede cartilage production, inhibit inflammatory, allergic, and immunologic responses, invoke shrinkage of lymphatic tissue, reduce the number of circulating lymphocytes, and affect the functions of the central nervous system. In humans, the most important ones are cortisol, cortisone, and corticosterone. Mineralocorticoids, uniuqely aldosterone in human, regulate the balance of water and promote retention of sodium, loss of potassium. Aldosterone plays a role also in promoting tissue repair. Spironolactone is the aldosterone antagonist called potassium-sparing diuretic used in the treatment of hypertension. Corticosteroids are used in clinically for hormonal replacement therapy, for suppression of ACTH, as antineoplastic, antiallergic, and anti-inflammatory agents, and to suppress immune responses.
  • Glucocorticoid Receptor Agonists
    • Dexamethasone
    • Triamcinolone
    • Hydrocortisone
    • Prednisone
  • Glucocorticoid Receptor Antagonists
    • Mifepristone
    • Onapristone
  • Mineralocorticoid Receptor Agonists
    • Aldosterone
  • Mineralocorticoid Receptor Antagonists
    • Spironolactone
    • Eplerenone

Dexamethasone, a synthetic glucocorticoid of an analogue of cortisol, is therapeutically used in the replacement for adrenal insufficiency and to treat inflammatory, arthritis  and certain forms of overactive immune response in a wide variety of disorders.  It is used as an antiemetic in cancer chemotherapy. It counteracts the development of edema. It is also used as a diagnostic context in the detection of urinary levels of cortisol and 17-hydroxycorticosteroid.  measured following administration of dexamethasone; cortisol secretion is suppressed in patients with Cushing's syndrome (glucocorticoid excess) but not in those with ectopic ACTH syndrome or adrenal tumors at 16 times the level used in replacement therapy; cortisol secretion is suppressed in normal patients but not in those with Cushing's syndrome at three to four times the level used in replacement therapy.  The chemical designation is (11beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione. Some esters and salts of dexamethasone are administered by intraarticular, intravenous, or intramuscular injection, by inhalation, or applied to the skin and conjunctiva. Examples are as follows;

  • Dexamethasone-17-acetate (CAS RN: 1177-87-3)
  • Dexamethasone Disodium Phosphate (CAS RN: 2392-39-4)
  • Dexamethasone Valerate (CAS RN: 14899-36-6)
  • Dexamethasone-21-isonicotinate (CAS RN: 2265-64-7)
  • Dexamethasone Palmitate (CAS RN: 33755-46-3)
  • Dexamethasone Propionate (CAS RN: 55541-30-5)
  • Dexamethasone Acefurate (CAS RN: 83880-70-0)
  • Dexamethasone-21-galactoside (CAS RN: 92901-23-0)
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

IDENTIFICATION

Complies

ASSAY
97.0 - 103.0%

OPTICAL ROTATION

+75° ~ +83°

pH

7.5 - 9.5

RELATED SUBSTANCE

Complies

FREE DEXAMETHASONE

1.0% max

FREE PHOSPHATE

1.0% max

ETHANOL

3.0% max

WATER

10.0% max
TRANSPORTATION
PACKING

 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-40-63, Safety Phrases: 36/37/39